Vice Presidential Disability
There are many criticisms that can be lodged against the Twenty-Fifth Amendment, and one of them is that there is no process for removing a disabled vice-president short of impeachment. If you think about it, this presents a serious problem.
Suppose the VP suffers a stroke. He or she cannot be fired by the President, unlike other significant executive officials. We can do without a functioning Vice President, but what if the President dies or resigns? Presumably the disabled VP would become President and then would be sidelined under the 25th Amendment. Then the Speaker of the House would become President (possibly from the other party). That Acting President could nominate his or her own Vice President (otherwise the next person in the succession would be the President Pro Tempore of the Senate), which in turn could mean that the disabled President (if he or she recovered) could wind up with a new VP not of his or her own choosing.
You could solve this by impeaching and removing a disabled VP without naming a replacement. Then if that VP recovered, the President could name the old VP as the new one. But would being ill constitute a “high crime and misdemeanor?” Some members of Congress might be reluctant to set a precedent like that.
Sooner or later, the idiocy of the Presidential Succession Statute, along with the flaws are the Twenty-Fifth Amendment, are going to cause a constitutional crisis.